Circular RNAs in Cancer

Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that are formed by precursor mRNA back-splicing or skipping events of thousands of genes in eukaryotes as covalently closed continuous loops. High-throughput sequencing and bioinformatics approaches have uncovered the broad expression of circRNAs across species. Their high stability, abundance, and evolutionary conservation among species points to their distinct properties and diverse cellular functions as efficient microRNAs and protein sponges; they also play important roles in modulating transcription and splicing. Additionally, most circRNAs are aberrantly expressed in pathological conditions and in a tissue-specific manner such…

• AC
  American Cancer Society
• OC
  Ovarian Cancer Research Fund
• NR
  National Research Foundation of Korea

  Award: NRF-2016M3A9B6903499
• NI
  National Institutes of Health

  Awards: R35 CA209904, CA016672, P50 CA217685, P50 CA098258, UH3TR000943