A Single‐Atom Nanozyme for Wound Disinfection Applications

Single-atom catalysts (SACs), as homogeneous catalysts, have been widely explored for chemical catalysis. However, few studies focus on the applications of SACs in enzymatic catalysis. Herein, we report that a zinc-based zeolitic-imidazolate-framework (ZIF-8)-derived carbon nanomaterial containing atomically dispersed zinc atoms can serve as a highly efficient single-atom peroxidase mimic. To reveal its structure-activity relationship, the structural evolution of the single-atom nanozyme (SAzyme) was systematically investigated. Furthermore, the coordinatively unsaturated active zinc sites and catalytic mechanism of the SAzyme are disclosed using density functional theory (DFT) calculations. The SAzyme, with…

• NN
  National Natural Science Foundation of China

  Awards: 51572271, 31871005, 21822802, 51772018, 31530026, 81671810
• NK
  National Key Research and Development Program of China

  Award: 2016YFA0201500