Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact

Being born small lays the foundation for short-term and long-term implications for life. Intrauterine or fetal growth restriction describes the pregnancy complication of pathological reduced fetal growth, leading to significant perinatal mortality and morbidity, and subsequent long-term deficits. Placental insufficiency is the principal cause of FGR, which in turn underlies a chronic undersupply of oxygen and nutrients to the fetus. The neonatal morbidities associated with FGR depend on the timing of onset of placental dysfunction and growth restriction, its severity, and the gestation at birth of the infant. In this review, we explore the pathophysiological mechanisms involved in the development of major…

• NH
  National Heart Foundation of Australia
• SG
  State Government of Victoria
• CP
  Cerebral Palsy Alliance
• MR
  Medical Research Council
• NH
  National Health and Medical Research Council