The novel roles of circRNAs in human cancer
Shanghai Jiao Tong University · Shanghai Ninth People's Hospital · +1 more institution
Abstract
Covalently closed single-stranded circular RNAs (circRNAs) consist of introns or exons and are widely present in eukaryotic cells. CircRNAs generally have low expression levels and relatively stable structures compared with messenger RNAs (mRNAs), most of which are located in the cytoplasm and often act in cell type and tissue-specific manners, indicating that they may serve as novel biomarkers. In recent years, circRNAs have gradually become a hotspot in the field of RNA and cancer research, but the functions of most circRNAs have not yet been discovered. Known circRNAs can affect the biogenesis of cancers in diverse ways, such as functioning as a microRNA (miRNA) sponges, combining with RNA binding proteins…
Citation impact
- FWCI
- 43.25
- Percentile
- 100%
- References
- 84
Authors
4Topics & keywords
- Biology
- Biogenesis
- Computational biology
- microRNA
- Circular RNA
- Intron
- RNA splicing
- RNA-binding protein
- Good health and well-being