Macrophages in wound healing: activation and plasticity

Macrophages are critically involved in wound healing, from dampening inflammation to clearing cell debris and coordinating tissue repair. Within the wound, the complexity of macrophage function is increasingly recognized, with adverse outcomes when macrophages are inappropriately activated, such as in fibrosis or chronic non-healing wounds. Recent advances in in vivo and translational wound models, macrophage-specific deletions and new technologies to distinguish macrophage subsets, have uncovered the vast spectrum of macrophage activation and effector functions. Here, we summarize the main players in wound-healing macrophage activation and function, including cytokines, apoptotic cells, nucleotides and…

• DO
  Division of Intramural Research, National Institute of Allergy and Infectious Diseases

  Awards: R21AI137830, R21AI135500
• NI
  National Institutes of Health

  Awards: R21AI137830, R21AI135500