Influenza Virus Neuraminidase Structure and Functions
Peter Doherty Institute · University of Melbourne · +1 more institution
Abstract
With the constant threat of emergence of a novel influenza virus pandemic, there must be continued evaluation of the molecular mechanisms that contribute to virulence. Although the influenza A virus surface glycoprotein neuraminidase (NA) has been studied mainly in the context of its role in viral release from cells, accumulating evidence suggests it plays an important, multifunctional role in virus infection and fitness. This review investigates the various structural features of NA, linking these with functional outcomes in viral replication. The contribution of evolving NA activity to viral attachment, entry and release of virions from infected cells, and maintenance of functional balance with the viral…
Citation impact
- FWCI
- 34.98
- Percentile
- 100%
- References
- 141
Authors
5- JMJulie McAuleyCorresponding
Peter Doherty Institute, University of Melbourne
- BGBrad Gilbertson
Peter Doherty Institute, University of Melbourne
- STSanja Trifkovic
Peter Doherty Institute, University of Melbourne, St. Jude Children's Research Hospital
- LELorena E. Brown
University of Melbourne, Peter Doherty Institute
- JLJennifer L. McKimm‐Breschkin
University of Melbourne, Peter Doherty Institute
Topics & keywords
- Neuraminidase
- Virus
- Virology
- Hemagglutinin (influenza)
- Context (archaeology)
- Biology
- Viral entry
- Viral replication
- Good health and well-being