reviewFrontiers in ImmunologyFeb 8, 2019GOLD OA

Cold Tumors: A Therapeutic Challenge for Immunotherapy

PBPaola BonaventuraTSTala ShekarianVAVincent AlcazerJVJenny Valladeau‐GuilemondSVSandrine Valsesia‐Wittmann

Inserm · Centre de Recherche en Cancérologie de Lyon · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Therapeutic monoclonal antibodies targeting immune checkpoints (ICPs) have changed the treatment landscape of many tumors. However, response rate remains relatively low in most cases. A major factor involved in initial resistance to ICP inhibitors is the lack or paucity of tumor T cell infiltration, characterizing the so-called "cold tumors." In this review, we describe the main mechanisms involved in the absence of T cell infiltration, including lack of tumor antigens, defect in antigen presentation, absence of T cell activation and deficit of homing into the tumor bed. We discuss then the different therapeutic approaches that could turn cold into hot tumors. In this way, specific therapies are proposed…

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1,127
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55.84
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100%
References
94
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Authors

8

Topics & keywords

Topics
Keywords
  • Chimeric antigen receptor
  • Immunotherapy
  • Cancer research
  • Antigen
  • Monoclonal antibody
  • Immune system
  • Medicine
  • Homing (biology)
UN Sustainable Development Goals
  • Good health and well-being
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