Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials

SummaryBackground Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysis of data from all large statin trials to compare the effects of statin therapy at different ages. Methods In this meta-analysis, randomised trials of statin therapy were eligible if they aimed to recruit at least 1000 participants with a scheduled treatment duration of at least 2 years. We analysed individual participant data from 22 trials (n=134 537) and detailed summary data from one trial (n=12 705) of statin therapy versus control, plus individual participant data from…

• NB
  NIHR Bristol Biomedical Research Centre
• CR
  Cancer Research UK
• NI
  National Institute for Health and Care Research
• BH
  British Heart Foundation
• NH
  National Heart Foundation of Australia
• MR
  Medical Research Council

  Award: MC_UU_00017/4
• NH
  National Health and Medical Research Council