Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease
JCJuliane Cristina Ribeiro FernandesSMStephanie Maia AcuñaJIJuliana Ide AokiLMLucile Maria Floeter‐WinterSMSandra Márcia Muxel
Indexed incrossrefdoajpubmed
Abstract
The identification of RNAs that are not translated into proteins was an important breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene expression. These non-coding RNAs can be divided into two main classes according to their length: short non-coding RNAs, such as microRNAs (miRNAs), and long non-coding RNAs (lncRNAs). The lncRNAs in association with other molecules can coordinate several physiological processes and their dysfunction may impact in several pathologies, including cancer and infectious diseases. They can control the flux of genetic information, such as chromosome structure modulation, transcription, splicing, messenger RNA (mRNA) stability, mRNA availability,…
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5Topics & keywords
Topics
Keywords
- Biology
- microRNA
- Gene
- Computational biology
- RNA splicing
- RNA
- Long non-coding RNA
- Gene expression
UN Sustainable Development Goals
- Good health and well-being
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