articleImmunityJan 25, 2019HYBRID OA

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

JSJulie SchulthessSPSumeet PandeyMCMelania CapitaniKRKévin Rue-AlbrechtICIsabelle C. Arnold

Nuffield Orthopaedic Centre · John Radcliffe Hospital · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Host microbial cross-talk is essential to maintain intestinal homeostasis. However, maladaptation of this response through microbial dysbiosis or defective host defense toward invasive intestinal bacteria can result in chronic inflammation. We have shown that macrophages differentiated in the presence of the bacterial metabolite butyrate display enhanced antimicrobial activity. Butyrate-induced antimicrobial activity was associated with a shift in macrophage metabolism, a reduction in mTOR kinase activity, increased LC3-associated host defense and anti-microbial peptide production in the absence of an increased inflammatory cytokine response. Butyrate drove this monocyte to macrophage differentiation program…

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993
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Topics & keywords

Topics
Keywords
  • Butyrate
  • Biology
  • Antimicrobial
  • Microbiology
  • Macrophage
  • Inflammation
  • Macrophage polarization
  • Short-chain fatty acid
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