A Review of Curcumin and Its Derivatives as Anticancer Agents

Cancer is the second leading cause of death in the world and one of the major public health problems. Despite the great advances in cancer therapy, the incidence and mortality rates of cancer remain high. Therefore, the quest for more efficient and less toxic cancer treatment strategies is still at the forefront of current research. Curcumin, the active ingredient of the Curcuma longa plant, has received great attention over the past two decades as an antioxidant, anti-inflammatory, and anticancer agent. In this review, a summary of the medicinal chemistry and pharmacology of curcumin and its derivatives in regard to anticancer activity, their main mechanisms of action, and cellular targets has been provided…

• RS
  Royal Society

  Awards: EP/N007174/1, RG160662, IE150457, EP/N023579/1, RG160662 and IE150457
• UO
  University of Sheffield

  Awards: EP/N007174/1, EP/N023579/1, RG160662
• EA
  Engineering and Physical Sciences Research Council

  Awards: EP/N007174/1, EP/N023579/1, EP/N007174/1, RG160662, EP/N023579/1, EP/N007174/1 and EP/N023579/1