Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA
Central South University · Xiangya Hospital Central South University · +4 more institutions
Abstract
The regulatory loop between long noncoding RNAs (lncRNAs) and microRNAs has a dynamic role in transcriptional and translational regulation, and is involved in cancer. However, the regulatory circuitry between lncRNAs and microRNAs in tumorigenesis remains elusive. Here we demonstrate that a nuclear lncRNA LINC00336 is upregulated in lung cancer and functions as an oncogene by acting as a competing endogenous RNA (ceRNAs). LINC00336 bound RNA-binding protein ELAVL1 (ELAV-like RNA-binding protein 1) using nucleotides 1901-2107 of LINC00336 and the RRM interaction domain and key amino acids (aa) of ELAVL1 (aa 101-213), inhibiting ferroptosis. Moreover, ELAVL1 increased LINC00336 expression by stabilizing its…
Citation impact
- FWCI
- 29.67
- Percentile
- 100%
- References
- 54
Authors
17- MWMin WangCorresponding
Central South University, Xiangya Hospital Central South University
- CMChao Mao
Central South University, Xiangya Hospital Central South University
- LOLianlian Ouyang
Central South University, Xiangya Hospital Central South University
- YLYating Liu
Central South University, Xiangya Hospital Central South University
- WLWeiwei Lai
Central South University, Xiangya Hospital Central South University
Topics & keywords
- Competing endogenous RNA
- Biology
- Carcinogenesis
- microRNA
- RNA
- RNA-binding protein
- Long non-coding RNA
- Cell biology
- Good health and well-being