Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study
Montreal General Hospital · Hôpital du Sacré-Cœur de Montréal · +38 more institutions
Abstract
Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. This provides an unprecedented opportunity to directly observe prodromal neurodegenerative states, and potentially intervene with neuroprotective therapy. For future neuroprotective trials, it is essential to accurately estimate phenoconversion rate and identify potential predictors of phenoconversion. This study assessed the neurodegenerative disease risk and predictors of neurodegeneration in a large multicentre cohort of iRBD. We combined prospective follow-up data from 24 centres of the International RBD Study Group. At baseline, patients with…
Citation impact
- FWCI
- 74.58
- Percentile
- 100%
- References
- 69
Authors
55- RBRonald B. PostumaCorresponding
Montreal General Hospital, Hôpital du Sacré-Cœur de Montréal, Canadian Sleep & Circadian Network, McGill University
- ÁIÁlex Iranzo
Biomedical Research Networking Center on Neurodegenerative Diseases, Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- MHMichele Hu
University of Oxford, Parkinson's UK
- BHBirgit Högl
Innsbruck Medical University
- BFBradley F. Boeve
Mayo Clinic in Arizona
Topics & keywords
- Parkinsonism
- Dementia
- REM sleep behavior disorder
- Psychiatry
- Sleep (system call)
- Psychology
- Medicine
- Clinical psychology
- Good health and well-being