reviewFrontiers in PhysiologyFeb 26, 2019GOLD OA

Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review

PLPengxu LeiTBTao BaiYSYuling Sun

First Affiliated Hospital of Zhengzhou University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Ferroptosis is a newly identified form of nonapoptotic regulated cell death (RCD) characterized by iron-dependent accumulation of lipid peroxides. It is morphologically and biochemically different from known types of cell death. Ferroptosis plays a vital role in the treatment of tumors, renal failure, and ischemia reperfusion injury (IRI). Inhibition of glutathione peroxidase 4 (GPX4), starvation of cysteine, and peroxidation of arachidonoyl (AA) trigger ferroptosis in the cells. Iron chelators, lipophilic antioxidants, and specific inhibitor prevent ferroptosis. Although massive researches have demonstrated the importance of ferroptosis in human, its mechanism is not really clear. In this review, we distanced…

Citation impact

520
total citations
FWCI
43.83
Percentile
100%
References
101
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • GPX4
  • Programmed cell death
  • Lipid peroxidation
  • Cell biology
  • Phospholipid-hydroperoxide glutathione peroxidase
  • Cell
  • Mechanism (biology)
  • Chemistry
UN Sustainable Development Goals
  • Good health and well-being
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