Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data

Prospective, population-based studies that recruit participants in mid-life are valuable resources for dementia research. Follow-up in these studies is often through linkage to routinely-collected healthcare datasets. We investigated the accuracy of these datasets for dementia case ascertainment in a validation study using data from UK Biobank-an open access, population-based study of > 500,000 adults aged 40-69 years at recruitment in 2006-2010. From 17,198 UK Biobank participants recruited in Edinburgh, we identified those with ≥ 1 dementia code in their linked primary care, hospital admissions or mortality data and compared their coded diagnoses to clinical expert adjudication of their full-text medical…

• DP
  Dementias Platform UK
• MR
  Medical Research Council

  Awards: MR/L023784/2, MR/P001823/1, MR/M024873/1, MR/K026992/1, MC_PC_17228, MR/P001823/1, MR/S004130/1, MR/L023784/1