reviewFrontiers in ImmunologyMar 6, 2019GOLD OA

Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy

VMValeria Mollica PoetaMMMatteo MassaraACArianna CapucettiRBRaffaella Bonecchi

Istituti di Ricovero e Cura a Carattere Scientifico · Humanitas University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Immunotherapy is a clinically validated treatment for many cancers to boost the immune system against tumor growth and dissemination. Several strategies are used to harness immune cells: monoclonal antibodies against tumor antigens, immune checkpoint inhibitors, vaccination, adoptive cell therapies (e.g., CAR-T cells) and cytokine administration. In the last decades, it is emerging that the chemokine system represents a potential target for immunotherapy. Chemokines, a large family of cytokines with chemotactic activity, and their cognate receptors are expressed by both cancer and stromal cells. Their altered expression in malignancies dictates leukocyte recruitment and activation, angiogenesis, cancer cell…

Citation impact

588
total citations
FWCI
33.75
Percentile
100%
References
138
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Immunotherapy
  • Chemokine
  • Immunology
  • CCR10
  • Chemokine receptor
  • Immune system
  • Metastasis
  • Angiogenesis
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding