An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases
Kaohsiung Medical University · Kaohsiung Medical University Chung-Ho Memorial Hospital · +2 more institutions
Abstract
Lysophosphatidylcholine (LPC) is increasingly recognized as a key marker/factor positively associated with cardiovascular and neurodegenerative diseases. However, findings from recent clinical lipidomic studies of LPC have been controversial. A key issue is the complexity of the enzymatic cascade involved in LPC metabolism. Here, we address the coordination of these enzymes and the derangement that may disrupt LPC homeostasis, leading to metabolic disorders. LPC is mainly derived from the turnover of phosphatidylcholine (PC) in the circulation by phospholipase A₂ (PLA₂). In the presence of Acyl-CoA, lysophosphatidylcholine acyltransferase (LPCAT) converts LPC to PC, which rapidly gets recycled by the Lands…
Citation impact
- FWCI
- 24.78
- Percentile
- 100%
- References
- 247
Authors
6- SLShi‐Hui Law
Kaohsiung Medical University
- MCMei-Lin Chan
Kaohsiung Medical University, Kaohsiung Medical University Chung-Ho Memorial Hospital, Mackay Memorial Hospital
- GKGopal K. Marathe
University of Mysore
- FPFarzana Parveen
Kaohsiung Medical University
- CCChu‐Huang Chen
Kaohsiung Medical University, Kaohsiung Medical University Chung-Ho Memorial Hospital
Topics & keywords
- Lysophosphatidylcholine
- Lysophosphatidic acid
- Lysophospholipase
- Autotaxin
- Enzyme
- Biochemistry
- Lipid metabolism
- Metabolism
- Good health and well-being
Funding
- JHJohns Hopkins University
- THTexas Heart InstituteAward: 765-64050
- MOMinistry of Science and Technology, TaiwanAwards: 105-2320-B-037-004-MY3, 107-2321-B-037-002-, 106-2314-B-037-069-
- KMKaohsiung Medical UniversityAwards: KMU-DK107012, KMU-TP105D14, TP105D14
- KMKaohsiung Medical University Chung-Ho Memorial Hospital