reviewClinical EpigeneticsFeb 11, 2019GOLD OA

The role and mechanisms of action of microRNAs in cancer drug resistance

WSWengong SiJSJiaying ShenHZHuilin ZhengWFWeimin Fan

Zhejiang University · Blood Center of Zhejiang Province · +3 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19-25 nt, which can regulate various target genes and are thus involved in the regulation of a variety of biological and pathological processes, including the formation and development of cancer. Drug resistance in cancer chemotherapy is one of the main obstacles to curing this malignant disease. Statistical data indicate that over 90% of the mortality of patients with cancer is related to drug resistance. Drug resistance of cancer chemotherapy can be caused by many mechanisms, such as decreased antitumor drug uptake, modified drug targets, altered cell cycle checkpoints, or increased DNA damage repair, among others. In recent years, many…

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670
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100%
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Authors

4

Topics & keywords

Topics
Keywords
  • microRNA
  • Biology
  • Drug resistance
  • Cell cycle
  • Cancer
  • Gene
  • Drug
  • Bioinformatics
UN Sustainable Development Goals
  • Good health and well-being
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