Reduced default mode network functional connectivity in patients with recurrent major depressive disorder
Chinese Academy of Sciences · Institute of Psychology, Chinese Academy of Sciences · +35 more institutions
Abstract
Major depressive disorder (MDD) is common and disabling, but its neuropathophysiology remains unclear. Most studies of functional brain networks in MDD have had limited statistical power and data analysis approaches have varied widely. The REST-meta-MDD Project of resting-state fMRI (R-fMRI) addresses these issues. Twenty-five research groups in China established the REST-meta-MDD Consortium by contributing R-fMRI data from 1,300 patients with MDD and 1,128 normal controls (NCs). Data were preprocessed locally with a standardized protocol before aggregated group analyses. We focused on functional connectivity (FC) within the default mode network (DMN), frequently reported to be increased in MDD. Instead, we…
Citation impact
- FWCI
- 37.37
- Percentile
- 100%
- References
- 42
Authors
65- CYChao‐Gan YanCorresponding
Chinese Academy of Sciences, Institute of Psychology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, New York University
- XCXiao Chen
Institute of Psychology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- LLLe Li
Institute of Psychology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- FXF. Xavier Castellanos
Nathan Kline Institute for Psychiatric Research, New York University
- TBTongjian Bai
Anhui Medical University
Topics & keywords
- Default mode network
- Major depressive disorder
- Functional magnetic resonance imaging
- Resting state fMRI
- Psychology
- Functional connectivity
- Psychiatry
- Neuroscience
- Reduced inequalities