MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer

MicroRNA-34 (miR-34) has been reported to be dysregulated in various human cancers and regarded as a tumor suppressive microRNA because of its synergistic effect with the well-known tumor suppressor p53. Along with the application of MRX34, the first tumor-targeted microRNA drug which based on miR-34a mimics, on phase I clinical trial (NCT01829971), the significance of miR-34 is increasingly recognized. miR-34 plays a crucial role on repressing tumor progression by involving in epithelial-mesenchymal transition (EMT) via EMT- transcription factors, p53 and some important signal pathways. Not only that, numerous preclinical researches revealed the giant potential of miR-34a on cancer therapy through diversiform…

• NN
  National Natural Science Foundation of China

  Awards: No. 31670952, No. 81702921, 81702921, 31670952
• RA
  Research and Innovation Foundation
• FR
  Fundamental Research Funds for the Central Universities

  Awards: No.2018CQDYSG0021, 2018CQDYSG0021