Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

Venegas, Daniela Parada; Fuente, Marjorie K. De la; Landskron, Glauben; González, Marı́a Julieta; Quera, Rodrigo; Dijkstra, Gerard; Harmsen, Hermie J. M.; Faber, Klaas Nico; Hermoso, Marcela A.

doi:10.3389/fimmu.2019.00277

reviewFrontiers in ImmunologyMar 11, 2019GOLD OA

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

DPDaniela Parada Venegas MKMarjorie K. De la Fuente GLGlauben Landskron MJMarı́a Julieta González RQRodrigo Quera

University Medical Center Groningen · University of Chile · +2 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Ulcerative colitis (UC) and Crohn's disease (CD), collectively known as Inflammatory Bowel Diseases (IBD), are caused by a complex interplay between genetic, immunologic, microbial and environmental factors. Dysbiosis of the gut microbiome is increasingly considered to be causatively related to IBD and is strongly affected by components of a Western life style. Bacteria that ferment fibers and produce short chain fatty acids (SCFAs) are typically reduced in mucosa and feces of patients with IBD, as compared to healthy individuals. SCFAs, such as acetate, propionate and butyrate, are important metabolites in maintaining intestinal homeostasis. Several studies have indeed shown that fecal SCFAs levels are…

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Topics

Keywords

Immune system
Inflammatory bowel disease
Short-chain fatty acid
Inflammatory Bowel Diseases
Immunology
Medicine
Chemistry
Biochemistry

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