reviewExperimental & Molecular MedicineMar 1, 2019GOLD OA

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

DEDaniel E. MurphyOGOlivier G. de JongMBMaarten BrouwerMJMatthew J. A. WoodGLGrégory Lavieu

University Medical Center Utrecht · Utrecht University · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Extracellular vesicles (EVs) are increasingly being recognized as mediators of intercellular signaling via the delivery of effector molecules. Interestingly, certain types of EVs are also capable of inducing therapeutic responses. For these reasons, the therapeutic potential of EVs is a topic of intense research, both in the context of drug delivery and regenerative medicine. However, to fully utilize EVs for therapeutic purposes, an improved understanding of the mechanisms by which they function would be highly advantageous. Here, the current state of knowledge regarding the cellular uptake and trafficking of EVs is reviewed, along with a consideration of how these pathways potentially influence the functions…

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694
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Authors

7

Topics & keywords

Topics
Keywords
  • Context (archaeology)
  • Extracellular vesicles
  • Effector
  • Extracellular vesicle
  • Function (biology)
  • Intracellular
  • Drug delivery
  • Biology
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