Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics

Liu, Shunjie; Zhou, Xin; Zhang, Haoke; Ou, Hanlin; Lam, Jacky W. Y.; Liu, Yang; Shi, Linqi; Ding, Dan; Tang, Ben Zhong

doi:10.1021/jacs.8b13889

articleJournal of the American Chemical SocietyMar 13, 2019Closed access

Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics

SLShunjie Liu XZXin Zhou HZHaoke Zhang HOHanlin Ou JWJacky W. Y. Lam

Hong Kong University of Science and Technology · Shanxi Medical University · +3 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Planar donor and acceptor (D-A) conjugated structures are generally believed to be the standard for architecting highly efficient photothermal theranostic agents, in order to restrict intramolecular motions in aggregates (nanoparticles). However, other channels of extra nonradiative decay may be blocked. Now this challenge is addressed by proposing an "abnormal" strategy based on molecular motion in aggregates. Molecular rotors and bulky alkyl chains are grafted to the central D-A core to lower intermolecular interaction. The enhanced molecular motion favors the formation of a dark twisted intramolecular charge transfer state, whose nonradiative decay enhances the photothermal properties. Result shows that…

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650

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Topics & keywords

Topics

Keywords

Chemistry
Photothermal therapy
Intramolecular force
Intermolecular force
Nanoparticle
Alkyl
Conjugated system
Molecule

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