Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients
Hadassah Medical Center · UPMC Health System · +25 more institutions
Abstract
Transcatheter aortic-valve replacement (TAVR) is an alternative to surgery in patients with severe aortic stenosis who are at increased risk for death from surgery; less is known about TAVR in low-risk patients.
We performed a randomized noninferiority trial in which TAVR with a self-expanding supraannular bioprosthesis was compared with surgical aortic-valve replacement in patients who had severe aortic stenosis and were at low surgical risk. When 850 patients had reached 12-month follow-up, we analyzed data regarding the primary end point, a composite of death or disabling stroke at 24 months, using Bayesian methods.
Citation impact
- FWCI
- 348.18
- Percentile
- 100%
- References
- 21
Authors
31- JJJeffrey J. PopmaCorresponding
Hadassah Medical Center, UPMC Health System
- GMG. Michael Deeb
University of Michigan, UPMC Health System
- SJSteven J. Yakubov
OhioHealth, Riverside Methodist Hospital, UPMC Health System
- MMMubashir Mumtaz
UPMC Central Pa, UPMC Health System, University of Pittsburgh Medical Center
- HGHemal Gada
UPMC Central Pa, UPMC Health System, University of Pittsburgh Medical Center
Topics & keywords
- Medicine
- Valve replacement
- Stenosis
- Cardiology
- Internal medicine
- Aortic valve stenosis
- Aortic valve replacement
- Surgery
- Good health and well-being