reviewInternational Journal of Molecular SciencesMar 14, 2019GOLD OA

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

MBMohamed-Reda BenmebarekCHClara H. KarchesBLBruno L. CadilhaSLStefanie LeschSEStefan Endres

Center for Integrated Protein Science Munich · German Center for Lung Research · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Effective adoptive T cell therapy (ACT) comprises the killing of cancer cells through the therapeutic use of transferred T cells. One of the main ACT approaches is chimeric antigen receptor (CAR) T cell therapy. CAR T cells mediate MHC-unrestricted tumor cell killing by enabling T cells to bind target cell surface antigens through a single-chain variable fragment (scFv) recognition domain. Upon engagement, CAR T cells form a non-classical immune synapse (IS), required for their effector function. These cells then mediate their anti-tumoral effects through the perforin and granzyme axis, the Fas and Fas ligand axis, as well as the release of cytokines to sensitize the tumor stroma. Their persistence in the host…

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Authors

6

Topics & keywords

Topics
Keywords
  • Chimeric antigen receptor
  • Cell biology
  • T cell
  • Granzyme
  • Cytotoxic T cell
  • Granzyme B
  • Antigen
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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