Recent Advances in Minisci‐Type Reactions

Reactions that involve the addition of carbon-centered radicals to basic heteroarenes, followed by formal hydrogen atom loss, have become widely known as Minisci-type reactions. First developed into a useful synthetic tool in the late 1960s by Minisci, this reaction type has been in constant use over the last half century by chemists seeking to functionalize heterocycles in a rapid and direct manner, avoiding the need for de novo heterocycle synthesis. Whilst the originally developed protocols for radical generation remain in active use today, they have been joined in recent years by a new array of radical generation strategies that allow use of a wider variety of radical precursors that often operate under…

• G
  GlaxoSmithKline
• EA
  Engineering and Physical Sciences Research Council

  Awards: EP/N005422/1, EP/N005422/1, 1918560
• ER
  European Research Council

  Award: StG757381