The Critical Role of RNA m6A Methylation in Cancer

Abstract Since the identification of the first RNA demethylase and the establishment of methylated RNA immunoprecipitation-sequencing methodology 6 to 7 years ago, RNA methylation has emerged as a widespread phenomenon and a critical regulator of transcript expression. This new layer of regulation is termed “epitranscriptomics.” The most prevalent RNA methylation, N6-methyladenosine (m6A), occurs in approximately 25% of transcripts at the genome-wide level and is enriched around stop codons, in 5′- and 3′-untranslated regions, and within long internal exons. RNA m6A modification regulates RNA splicing, translocation, stability, and translation into protein. m6A is catalyzed by the RNA methyltransferases…

• CI
  Cancer Institute NSW
• DF
  Deutsche Forschungsgemeinschaft
• UO
  University of New South Wales
• NI
  National Institutes of Health

  Award: R21 CA226959
• MR
  Medical Research Council
• CC
  Cancer Council NSW