reviewFrontiers in ImmunologyMar 27, 2019GOLD OA

Advances in mRNA Vaccines for Infectious Diseases

CZCuiling ZhangGMGiulietta MaruggiHSHu ShanJLJunwei Li

Qingdao Agricultural University · GlaxoSmithKline (United States)

PubMed
Indexed incrossrefdoajpubmed

Abstract

During the last two decades, there has been broad interest in RNA-based technologies for the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have shown that mRNA vaccines provide a safe and long-lasting immune response in animal models and humans. In this review, we summarize current research progress on mRNA vaccines, which have the potential to be quick-manufactured and to become powerful tools against infectious disease and we highlight the bright future of their design and applications.

Citation impact

680
total citations
FWCI
37.34
Percentile
100%
References
172
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Infectious disease (medical specialty)
  • Medicine
  • Immune system
  • Clinical trial
  • Immunology
  • Disease
  • Computational biology
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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