Biodegradable Biomimic Copper/Manganese Silicate Nanospheres for Chemodynamic/Photodynamic Synergistic Therapy with Simultaneous Glutathione Depletion and Hypoxia Relief
University of Science and Technology Beijing
Abstract
The integration of reactive oxygen species (ROS)-involved photodynamic therapy (PDT) and chemodynamic therapy (CDT) holds great promise for enhanced anticancer effects. Herein, we report biodegradable cancer cell membrane-coated mesoporous copper/manganese silicate nanospheres (mCMSNs) with homotypic targeting ability to the cancer cell lines and enhanced ROS generation through singlet oxygen (1O2) production and glutathione (GSH)-activated Fenton reaction, showing excellent CDT/PDT synergistic therapeutic effects. We demonstrate that mCMSNs are able to relieve the tumor hypoxia microenvironment by catalytic decomposition of endogenous H2O2 to O2 and further react with O2 to produce toxic 1O2 with a 635 nm…
Citation impact
- FWCI
- 41.66
- Percentile
- 100%
- References
- 69
Authors
9Topics & keywords
- Photodynamic therapy
- Reactive oxygen species
- Glutathione
- Chemistry
- Tumor microenvironment
- Singlet oxygen
- Cancer cell
- Hydroxyl radical
Funding
- NNNational Natural Science Foundation of ChinaAwards: 21475008, 21874008
- MOMinistry of Education of the People's Republic of ChinaAward: FRF-BD-17-016A
- MOMinistry of Science and Technology of the People's Republic of ChinaAwards: 2016YFC0106602, 2016YFC0106601
- BMBeijing Municipal Science and Technology CommissionAward: z131102002813058