reviewAntioxidantsMar 25, 2019GOLD OA

Measurement and Clinical Significance of Lipid Peroxidation as a Biomarker of Oxidative Stress: Oxidative Stress in Diabetes, Atherosclerosis, and Chronic Inflammation

FIFumiaki ItoYSYoko SonoTITomoyuki Ito

Sunstar (Japan) · Kyoto Prefectural University of Medicine

PubMed
Indexed incrossrefdoajpubmed

Abstract

Endothelial dysfunction is one of the initial steps in the pathogenesis of atherosclerosis and development of cardiovascular disease in patients with diabetes mellitus. Several risk factors are associated with endothelial dysfunction and atherosclerosis, such as hypertension, dyslipidaemia, inflammation, oxidative stress, and advanced glycation-end products. Among these risk factors, oxidative stress is the largest contributor to the formation of atherosclerotic plaques. Measurement of reactive oxygen species (ROS) is still difficult, and assays for the measurement of ROS have failed to show a consistent correlation between pathological states and oxidative stress. To solve this problem, this review summarizes…

Citation impact

505
total citations
FWCI
32.07
Percentile
100%
References
159
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • Oxidative stress
  • Lipid peroxidation
  • Diabetes mellitus
  • Inflammation
  • Glycation
  • Endothelial dysfunction
  • Pathogenesis
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding