Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder
Fifth Affiliated Hospital of Zhengzhou University · Zhengzhou University · +2 more institutions
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by impairments in social interactions and communication, restricted interests and repetitive behaviors. Several studies report a high prevalence of gastrointestinal (GI) symptoms in autistic individuals. Cumulative evidence reveals that the gut microbiota and its metabolites (especially short-chain fatty acids, SCFAs) play an important role in GI disorders and the pathogenesis of ASD. However, the composition of the gut microbiota and its association with fecal SCFAs and GI symptoms of autistic children remain largely unknown. In the present study, we sequenced the bacterial 16S rRNA gene, detected fecal SCFAs, assessed GI…
Citation impact
- FWCI
- 18.88
- Percentile
- 100%
- References
- 43
Authors
11Topics & keywords
- Lachnospiraceae
- Gut flora
- Autism spectrum disorder
- Feces
- Butyrate
- Neurodevelopmental disorder
- Biology
- Short-chain fatty acid