The lncRNA Neat1 promotes activation of inflammasomes in macrophages
University of Science and Technology of China · Chinese Academy of Sciences · +7 more institutions
Abstract
The inflammasome has an essential function in innate immune, responding to a wide variety of stimuli. Here we show that the lncRNA Neat1 promotes the activation of several inflammasomes. Neat1 associates with the NLRP3, NLRC4, and AIM2 inflammasomes in mouse macrophages to enhance their assembly and subsequent pro-caspase-1 processing. Neat1 also stabilizes the mature caspase-1 to promote interleukin-1β production and pyroptosis. Upon stimulation with inflammasome-activating signals, Neat1, which normally resides in the paraspeckles, disassociates from these nuclear bodies and translocates to the cytoplasm to modulate inflammasome activation using above mechanism. Neat1 is also up-regulated under hypoxic…
Citation impact
- FWCI
- 24.10
- Percentile
- 100%
- References
- 71
Authors
5- PZPengfei Zhang
University of Science and Technology of China, Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science
- LCLimian Cao
University of Science and Technology of China, Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science
- RZRongbin Zhou
University of Science and Technology of China, Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science
- XYXiaolu YangCorresponding
Cancer Research Institute, UPMC Hillman Cancer Center, University of Pennsylvania
- MWMian WuCorresponding
Henan University, Zhengzhou University, Center for Excellence in Molecular Cell Science, Henan Provincial People's Hospital
Topics & keywords
- Inflammasome
- Pyroptosis
- NLRC4
- AIM2
- Innate immune system
- Cell biology
- Caspase 1
- Biology