The Sleep-Immune Crosstalk in Health and Disease
Beth Israel Deaconess Medical Center · Harvard University · +2 more institutions
Abstract
Sleep and immunity are bidirectionally linked. Immune system activation alters sleep, and sleep in turn affects the innate and adaptive arm of our body's defense system. Stimulation of the immune system by microbial challenges triggers an inflammatory response, which, depending on its magnitude and time course, can induce an increase in sleep duration and intensity, but also a disruption of sleep. Enhancement of sleep during an infection is assumed to feedback to the immune system to promote host defense. Indeed, sleep affects various immune parameters, is associated with a reduced infection risk, and can improve infection outcome and vaccination responses. The induction of a hormonal constellation that…
Citation impact
- FWCI
- 107.24
- Percentile
- 100%
- References
- 607
Authors
3- LBLuciana BesedovskyCorresponding
Beth Israel Deaconess Medical Center, Harvard University, University of Tübingen, University of Lübeck
- TLTanja Lange
Beth Israel Deaconess Medical Center, Harvard University, University of Tübingen, University of Lübeck
- MHMonika Haack
Beth Israel Deaconess Medical Center, Harvard University, University of Tübingen, University of Lübeck
Topics & keywords
- Immune system
- Sleep (system call)
- Inflammation
- Immunology
- Sleep deprivation
- Crosstalk
- Disease
- Innate immune system
- Good health and well-being