Post-stress bacterial cell death mediated by reactive oxygen species
Rutgers, The State University of New Jersey · Xiamen University · +1 more institution
Abstract
Antimicrobial efficacy, which is central to many aspects of medicine, is being rapidly eroded by bacterial resistance. Since new resistance can be induced by antimicrobial action, highly lethal agents that rapidly reduce bacterial burden during infection should help restrict the emergence of resistance. To improve lethal activity, recent work has focused on toxic reactive oxygen species (ROS) as part of the bactericidal activity of diverse antimicrobials. We report that when Escherichia coli was subjected to antimicrobial stress and the stressor was subsequently removed, both ROS accumulation and cell death continued to occur. Blocking ROS accumulation by exogenous mitigating agents slowed or inhibited…
Citation impact
- FWCI
- 13.59
- Percentile
- 100%
- References
- 62
Authors
5- YHYuzhi HongCorresponding
Rutgers, The State University of New Jersey
- JZJie Zeng
Xiamen University
- XWXiuhong Wang
Rutgers, The State University of New Jersey, Harbin Medical University
- KDKarl Drlica
Rutgers, The State University of New Jersey
- XZXilin Zhao
Rutgers, The State University of New Jersey, Xiamen University
Topics & keywords
- Reactive oxygen species
- Antimicrobial
- DNA damage
- Catalase
- Oxidative stress
- Programmed cell death
- SOS response
- Microbiology
- Good health and well-being