Epithelial cell–derived cytokines: more than just signaling the alarm
Virginia Mason Medical Center · Benaroya Research Institute · +1 more institution
Abstract
The epithelial cell–derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 are central regulators of type 2 immunity, which drives a broad array of allergic responses. Often characterized as “alarmins” that are released by the barrier epithelium in response to external insults, these epithelial cell–derived cytokines were initially thought to act only early in allergic inflammation. Indeed, TSLP can condition dendritic cells to initiate type 2 responses, and IL-33 may influence susceptibility to asthma through its role in establishing the immune environment in the perinatal lungs. However, TSLP, IL-33, and IL-25 all regulate a broad spectrum of innate immune cell populations and are…
Citation impact
- FWCI
- 18.80
- Percentile
- 100%
- References
- 195
Authors
3Topics & keywords
- Thymic stromal lymphopoietin
- Innate lymphoid cell
- Immunology
- Allergic inflammation
- Immune system
- Innate immune system
- Biology
- Inflammation
- Good health and well-being