Claudin-5: gatekeeper of neurological function
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Abstract
Tight junction proteins of the blood-brain barrier are vital for maintaining integrity of endothelial cells lining brain blood vessels. The presence of these protein complexes in the space between endothelial cells creates a dynamic, highly regulated and restrictive microenvironment that is vital for neural homeostasis. By limiting paracellular diffusion of material between blood and brain, tight junction proteins provide a protective barrier preventing the passage of unwanted and potentially damaging material. Simultaneously, this protective barrier hinders the therapeutic effectiveness of central nervous system acting drugs with over 95% of small molecule therapeutics unable to bypass the blood-brain…
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561
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- 22.90
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Authors
3Topics & keywords
Topics
Keywords
- Blood–brain barrier
- Tight junction
- Claudin
- Paracellular transport
- Neuroscience
- Homeostasis
- Medicine
- Occludin
UN Sustainable Development Goals
- Good health and well-being
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