Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations
Philadelphia VA Medical Center · University of Pennsylvania · +9 more institutions
Abstract
Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately heritable traits. We conduct genome-wide association studies of these traits using longitudinal Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) scores and AUD diagnoses in a multi-ancestry Million Veteran Program sample (N = 274,424). We identify 18 genome-wide significant loci: 5 associated with both traits, 8 associated with AUDIT-C only, and 5 associated with AUD diagnosis only. Polygenic Risk Scores (PRS) for both traits are associated with alcohol-related disorders in two independent samples. Although a significant genetic correlation reflects the overlap between the traits, genetic correlations for 188…
Citation impact
- FWCI
- 44.83
- Percentile
- 100%
- References
- 66
Authors
20- HRHenry R. KranzlerCorresponding
Philadelphia VA Medical Center, University of Pennsylvania
- HZHang Zhou
Yale University, VA Connecticut Healthcare System
- RLRachel L. Kember
Veterans Health Administration, University of Pennsylvania
- RVRachel Vickers‐Smith
University of Louisville, Veterans Health Administration
- ACAmy C. Justice
Yale University, VA Connecticut Healthcare System
Topics & keywords
- Heritability
- Genome-wide association study
- Alcohol use disorder
- Alcohol consumption
- Genetic correlation
- Genetic association
- Alcohol Use Disorders Identification Test
- Genetics
- Good health and well-being