Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis
Central South University · Xiangya Hospital Central South University · +2 more institutions
Abstract
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions. Although there is anatomical separation, emerging evidence has indicated the existence of bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), and brain. The cross-talk between gut microbiota and brain may have crucial impact during basic neurogenerative processes, in neurodegenerative disorders and tumors of CNS. In this review, we discuss the biological interplay between gut-brain axis, and further explore how this…
Citation impact
- FWCI
- 30.67
- Percentile
- 100%
- References
- 205
Authors
6- QMQianquan Ma
Central South University, Xiangya Hospital Central South University, Houston Methodist
- CXChangsheng Xing
Houston Methodist
- WLWenyong Long
Central South University, Xiangya Hospital Central South University
- HYHelen Y. Wang
Houston Methodist
- QLQing Liu
Central South University, Xiangya Hospital Central South University
Topics & keywords
- Gut flora
- Central nervous system
- Neuroscience
- Gut–brain axis
- Neurology
- Enteric nervous system
- Biology
- Pathological
Funding
- UDU.S. Department of DefenseAward: BC151081
- CPCancer Prevention and Research Institute of TexasAwards: RP150611, DP150099, RP150611 and RP170537, RP170537, DP150099
- NINational Institutes of HealthAwards: R01CA101795 and U54CA210181, R01CA101795, U54CA210181
- NCNational Cancer InstituteAwards: R01CA101795, U54CA210181
- CDCongressionally Directed Medical Research Programs