Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets
University of Edinburgh · MRC Centre for Reproductive Health · +9 more institutions
Abstract
The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human cancer are poorly understood. Here, we show that monocyte subpopulation distribution and transcriptomes are significantly altered by the presence of endometrial and breast cancer. Furthermore, TAMs from endometrial and breast cancers are transcriptionally distinct from monocytes and their respective tissue-resident macrophages. We identified a breast TAM signature that is highly enriched in aggressive breast cancer subtypes and associated with shorter disease-specific survival. We also identified an auto-regulatory loop between TAMs and cancer cells driven by tumor necrosis factor alpha involving SIGLEC1 and CCL8, which is…
Citation impact
- FWCI
- 42.42
- Percentile
- 100%
- References
- 64
Authors
22- LCLuca Cassetta
University of Edinburgh, MRC Centre for Reproductive Health, Queen's Medical Centre
- SFStamatina Fragkogianni
MRC Centre for Reproductive Health, Queen's Medical Centre, University of Edinburgh
- AHAndrew H. Sims
Edinburgh Cancer Research
- ASAgnieszka Swierczak
Queen's Medical Centre, University of Edinburgh, MRC Centre for Reproductive Health
- LMLesley M. Forrester
University of Edinburgh, MRC Centre for Regenerative Medicine
Topics & keywords
- Monocyte
- Reprogramming
- Macrophage
- Transcriptome
- Breast cancer
- Cancer research
- Biology
- Cancer
- Good health and well-being