Prognosis and improved outcomes in major depression: a review
National Institutes of Health · National Institute of Mental Health · +1 more institution
Abstract
Treatment outcomes for major depressive disorder (MDD) need to be improved. Presently, no clinically relevant tools have been established for stratifying subgroups or predicting outcomes. This literature review sought to investigate factors closely linked to outcome and summarize existing and novel strategies for improvement. The results show that early recognition and treatment are crucial, as duration of untreated depression correlates with worse outcomes. Early improvement is associated with response and remission, while comorbidities prolong course of illness. Potential biomarkers have been explored, including hippocampal volumes, neuronal activity of the anterior cingulate cortex, and levels of…
Citation impact
- FWCI
- 39.36
- Percentile
- 100%
- References
- 210
Authors
5- CKChristoph KrausCorresponding
National Institutes of Health, National Institute of Mental Health, Medical University of Vienna
- BKBashkim Kadriu
National Institutes of Health, National Institute of Mental Health
- RLRupert Lanzenberger
Medical University of Vienna
- CACarlos A. Zarate
National Institutes of Health, National Institute of Mental Health
- SKSiegfried Kasper
Medical University of Vienna
Topics & keywords
- Anterior cingulate cortex
- Medicine
- Electroconvulsive therapy
- Depression (economics)
- Treatment-resistant depression
- Major depressive disorder
- Neurotrophic factors
- Translocator protein
- Good health and well-being