reviewInternational Journal of Molecular SciencesApr 4, 2019GOLD OA

Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2

TKToshihisa Komori

Nagasaki University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells, and its expression is upregulated in preosteoblasts, reaches the maximal level in immature osteoblasts, and is down-regulated in mature osteoblasts. Runx2 enhances the proliferation of osteoblast progenitors by directly regulating Fgfr2 and Fgfr3. Runx2 enhances the proliferation of suture mesenchymal cells and induces their commitment into osteoblast lineage cells through the direct regulation of hedgehog (Ihh, Gli1, and Ptch1), Fgf (Fgfr2 and Fgfr3), Wnt (Tcf7, Wnt10b, and Wnt1), and Pthlh (Pthr1) signaling pathway genes, and Dlx5. Runx2…

Citation impact

814
total citations
FWCI
26.15
Percentile
100%
References
79
Citations per year

Authors

1

Topics & keywords

Topics
Keywords
  • RUNX2
  • Osteoblast
  • Mesenchymal stem cell
  • Cell biology
  • Indian hedgehog
  • Wnt signaling pathway
  • Chondrocyte
  • Progenitor cell
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