Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice
Jinan University · State Administration of Traditional Chinese Medicine of the People's Republic of China · +1 more institution
Abstract
Abstract In this study, we investigated lipopolysaccharide (LPS)-induced cognitive impairment and neuroinflammation in C57BL/6J mice by using behavioral tests, immunofluorescence, enzyme-linked immunosorbent assay (ELISA) and Western blot. We found that LPS treatment leads to sickness behavior and cognitive impairment in mice as shown in the Morris water maze and passive avoidance test, and these effects were accompanied by microglia activation (labeled by ionized calcium binding adaptor molecule-1, IBA-1) and neuronal cell loss (labeled by microtubule-associated protein 2, MAP-2) in the hippocampus. The levels of interleukin-4 (IL-4) and interleukin-10 (IL-10) in the serum and brain homogenates were reduced…
Citation impact
- FWCI
- 40.71
- Percentile
- 100%
- References
- 65
Authors
12- JZJiayi ZhaoCorresponding
Jinan University, State Administration of Traditional Chinese Medicine of the People's Republic of China
- WBWei Bi
First Affiliated Hospital of Jinan University
- SXShu Xiao
Jinan University, State Administration of Traditional Chinese Medicine of the People's Republic of China
- XLXin Lan
Jinan University, State Administration of Traditional Chinese Medicine of the People's Republic of China
- XCXiaofeng Cheng
First Affiliated Hospital of Jinan University
Topics & keywords
- Neuroinflammation
- Microglia
- Western blot
- Nitric oxide synthase
- Morris water navigation task
- Lipopolysaccharide
- Pharmacology
- Nitric oxide
- Good health and well-being