Elimination Pathways of Nanoparticles
University of Toronto · Oklahoma State University Oklahoma City · +2 more institutions
Abstract
Understanding how nanoparticles are eliminated from the body is required for their successful clinical translation. Many promising nanoparticle formulations for in vivo medical applications are large (>5.5 nm) and nonbiodegradable, so they cannot be eliminated renally. A proposed pathway for these nanoparticles is hepatobiliary elimination, but their transport has not been well-studied. Here, we explored the barriers that determined the elimination of nanoparticles through the hepatobiliary route. The route of hepatobiliary elimination is usually through the following pathway: (1) liver sinusoid, (2) space of Disse, (3) hepatocytes, (4) bile ducts, (5) intestines, and (6) out of the body. We discovered that…
Citation impact
- FWCI
- 21.83
- Percentile
- 100%
- References
- 47
Authors
7Topics & keywords
- Nanoparticle
- Nanotechnology
- In vivo
- Sinusoid
- Chemistry
- Materials science
- Biology
- Immunology