White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities

Alber, Jessica; Alladi, Suvarna; Bae, Hee‐Joon; Barton, David A.; Beckett, Laurel; Bell, Joanne M.; Berman, Sara E.; Biessels, Geert Jan; Black, Sandra E.; Bos, Isabelle; Bowman, Gene L.; Brai, Emanuele; Brickman, Adam M.; Callahan, Brandy L.; Corriveau, Roderick A.; Fossati, Silvia; Gottesman, Rebecca F.; Gustafson, Deborah; Hachinski, Vladimir; Hayden, Kathleen M.; Helman, Alex M.; Hughes, Timothy M.; Isaacs, Jeremy D.; Jefferson, Angela L.; Johnson, Sterling C.; Kapasi, Alifiya; Kern, Silke; Kwon, Jay C.; Kukolja, Juraj; Lee, Athene; Lockhart, Samuel N.; Murray, Anne M.; Osborn, Katie E.; Power, Melinda C.; Price, Brittani R.; Rhodius‐Meester, Hanneke; Rondeau, Jacqueline A.; Rosen, Allyson; Rosene, Douglas L.; Schneider, Julie A.; Scholtzova, Henrieta; Shaaban, C. Elizabeth; Silva, Nárlon Cássio Boa Sorte; Snyder, Heather M.; Swardfager, Walter; Troen, Aron M.; Veluw, Susanne J. van; Vemuri, Prashanthi; Wallin, Anders; Wellington, Cheryl L.; Wilcock, Donna M.; Xie, Sharon X.; Hainsworth, Atticus H.

doi:10.1016/j.trci.2019.02.001

reviewAlzheimer s & Dementia Translational Research & Clinical InterventionsJan 1, 2019GOLD OA

White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities

JAJessica Alber SASuvarna Alladi HBHee‐Joon Bae DADavid A. Barton LBLaurel Beckett

University of Rhode Island · National Institute of Mental Health and Neurosciences · +60 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it…

Citation impact

440

total citations

FWCI: 32.71
Percentile: 100%
References: 67

Citations per year

Authors

53

Topics & keywords

Topics

Keywords

Hyperintensity
Dementia
Psychology
Cognition
Cognitive decline
Disease
Neuroscience
Magnetic resonance imaging

No related works found for this paper.