Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
University of Luxembourg · Luxembourg Institute of Health · +7 more institutions
Abstract
The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and resistance have been challenged in brain tumors. Here we report that cells expressing CSC-associated cell membrane markers in Glioblastoma (GBM) do not represent a clonal entity defined by distinct functional properties and transcriptomic profiles, but rather a plastic state that most cancer cells can adopt. We show that phenotypic heterogeneity arises from non-hierarchical, reversible state transitions, instructed by the microenvironment and is predictable by mathematical modeling. Although functional stem cell properties were similar in vitro, accelerated reconstitution of heterogeneity provides a growth advantage in vivo,…
Citation impact
- FWCI
- 32.53
- Percentile
- 100%
- References
- 69
Authors
22- ADAnne DirkseCorresponding
University of Luxembourg, Luxembourg Institute of Health, Luxembourg Institute of Science and Technology
- AGAnna Golebiewska
Luxembourg Institute of Health
- TBThomas Buder
HTW Berlin - University of Applied Sciences, Hochschule für Technik und Wirtschaft Dresden – University of Applied Sciences, Technische Universität Dresden
- PVPetr V. Nazarov
Luxembourg Institute of Health
- AMArnaud Muller
Luxembourg Institute of Health
Topics & keywords
- Cancer stem cell
- Biology
- Tumor microenvironment
- Stem cell
- Cancer cell
- Phenotype
- Transcriptome
- Glioblastoma
- Good health and well-being