Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment
Universidad de Granada · Instituto de Investigación Biosanitaria de Granada · +1 more institution
Abstract
Many therapeutically active molecules are non-soluble in aqueous systems, chemically and biologically fragile or present severe side effects. Lipid-based nanoparticle (LBNP) systems represent one of the most promising colloidal carriers for bioactive organic molecules. Their current application in oncology has revolutionized cancer treatment by improving the antitumor activity of several chemotherapeutic agents. LBNPs advantages include high temporal and thermal stability, high loading capacity, ease of preparation, low production costs, and large-scale industrial production since they can be prepared from natural sources. Moreover, the association of chemotherapeutic agents with lipid nanoparticles reduces…
Citation impact
- FWCI
- 18.71
- Percentile
- 100%
- References
- 137
Authors
7- BGBeatriz García-Pinel
Universidad de Granada, Instituto de Investigación Biosanitaria de Granada
- CPCristina Porras-Alcalá
Universidad de Málaga
- AOAlicia Ortega-Rodríguez
Universidad de Málaga
- FSFrancisco Sarabia
Universidad de Málaga
- JPJosé PradosCorresponding
Universidad de Granada, Instituto de Investigación Biosanitaria de Granada
Topics & keywords
- Cancer treatment
- In vivo
- Cancer
- Solid lipid nanoparticle
- Drug
- Pharmacology
- Cancer therapy
- Therapeutic index
- Good health and well-being