Principles of genome folding into topologically associating domains

Understanding the mechanisms that underlie chromosome folding within cell nuclei is essential to determine the relationship between genome structure and function. The recent application of "chromosome conformation capture" techniques has revealed that the genome of many species is organized into domains of preferential internal chromatin interactions called "topologically associating domains" (TADs). This chromosome chromosome folding has emerged as a key feature of higher-order genome organization and function through evolution. Although TADs have now been described in a wide range of organisms, they appear to have specific characteristics in terms of size, structure, and proteins involved in their formation.…

• AN
  Agence Nationale de la Recherche

  Award: ANR-15-CE12-0006 EpiDevoMath
• FP
  Fondation pour la Recherche Médicale

  Award: DEI20151234396
• LC
  Ligue Contre le Cancer
• CN
  Centre National de la Recherche Scientifique