3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts

Generation of thick vascularized tissues that fully match the patient still remains an unmet challenge in cardiac tissue engineering. Here, a simple approach to 3D-print thick, vascularized, and perfusable cardiac patches that completely match the immunological, cellular, biochemical, and anatomical properties of the patient is reported. To this end, a biopsy of an omental tissue is taken from patients. While the cells are reprogrammed to become pluripotent stem cells, and differentiated to cardiomyocytes and endothelial cells, the extracellular matrix is processed into a personalized hydrogel. Following, the two cell types are separately combined with hydrogels to form bioinks for the parenchymal cardiac…

• MO
  Ministry of Science, Technology and Space

  Awards: 3-12587, 3‐12587
• IS
  Israel Science Foundation

  Award: 700/13
• TA
  Tel Aviv University
• ER
  European Research Council

  Award: 637943