Brain organoids: advances, applications and challenges

Brain organoids are self-assembled three-dimensional aggregates generated from pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic human brain. As such, they have emerged as novel model systems that can be used to investigate human brain development and disorders. Although brain organoids mimic many key features of early human brain development at molecular, cellular, structural and functional levels, some aspects of brain development, such as the formation of distinct cortical neuronal layers, gyrification, and the establishment of complex neuronal circuitry, are not fully recapitulated. Here, we summarize recent advances in the development of brain organoid methodologies…

• SF
  Simons Foundation

  Award: 575050
• NI
  National Institutes of Health

  Awards: R01MH105128, P01NS097206, U19MH106434, R35NS097370, R37NS047344, U19AI131130