articleAdvanced MaterialsApr 12, 2019Closed access

Ultrasmall Oxygen‐Deficient Bimetallic Oxide MnWO X Nanoparticles for Depletion of Endogenous GSH and Enhanced Sonodynamic Cancer Therapy

FGFei GongLCLiang ChengNYNailin YangOBOshra BetzerLFLiangzhu Feng

Soochow University · Bar-Ilan University · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Abstract Sonodynamic therapy (SDT) triggered by ultrasound (US) has attracted increasing attention owing to its abilities to overcome critical limitations including low tissue‐penetration depth and phototoxicity in photodynamic therapy. Herein, the design of a new type of sonosensitizer is revealed, namely, ultrasmall oxygen‐deficient bimetallic oxide MnWO X nanoparticles, for multimodal imaging‐guided enhanced SDT against cancer. As‐made MnWO X nanoparticles with poly(ethylene glycol) (PEG) modification show high physiological stability and biocompatibility. Interestingly, such MnWO X ‐PEG nanoparticles exhibit highly efficient US‐triggered production of 1 O 2 and •OH, higher than that of previously reported…

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528
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100%
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Authors

10

Topics & keywords

Topics
Keywords
  • Sonodynamic therapy
  • Materials science
  • PEG ratio
  • Ethylene glycol
  • Biophysics
  • Nanoparticle
  • Biocompatibility
  • Nanotechnology
UN Sustainable Development Goals
  • Good health and well-being
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